Scientists claim to have found a permanent solution to the problem of body rejection in organ transplantation. Accordingly, organ transplantation will become easier with a new antibody produced in the laboratory. For now, the antibody has been successful in experiments conducted on monkeys. In the first trials, antibodies were tested for kidney and pancreas transplantation.
Does the problem of body rejection in organ transplantation end?
Researchers managed to prevent the body from rejecting the organ after kidney and pancreas transplantation with the antibody they called tegoprubart (AT-1501).
In fact, this antibody was developed for ALS disease. In this sense, the non-profit ALS Therapy and Development Institute conducted this research and development. The antibody has emerged in human trials for ALS patients, with hints that it may also help organ transplant patients.
Accordingly, the antibody targets a molecule produced by T cells. In this sense, it turns out that it suppresses a specific type of immune response that is common in ALS.
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So he wanted to see if the same response would work for organ transplant patients. The antibody was tested on monkeys that received organ transplants. The antibody used in kidney and pancreatic islet cell transplants prevented the body from mounting an immune response.
This is especially hopeful for patients who have to use immune-suppressing drugs after organ donation. Again, no clotting problems occurred after the treatment.
Scientists tried an antibody in a similar area years ago, but it caused clotting. For this reason, body rejection in organ transplantation has become one of the unsolved problems for years.
One of the most troublesome patient groups in organ transplants is kidney transplant patients. In this sense, the problem of body rejection in organ transplantation affects kidney transplant patients the most. In this sense, researchers also focused on this in their experiments with monkeys.