What is Quadrupedal Syndrome (Üner Tan Syndrome)?

people with their hands and feet on the ground; a kind of quadrupedal syndrome, which causes them to walk on all fours, or also called Uner Tan syndromeIt is a disease that was first observed in our country and entered the medical literature.

Thanks to the researches of the evolutionary biologist Üner Tan on the disease, also known as the four-legged syndrome, the disease has been diagnosed in medicine worldwide.Uner Tan Syndrome’ trying. This precious evolutionary biologist passed away at the age of 85. We wanted to explain simply what the four-legged syndrome, named in his memory, is.

What is the four-legged syndrome / Üner Tan syndrome?

Uner Tan syndrome is a type of disease in which people experience loss of balance and coordination, along with cognitive disorders. Uner Tan syndrome not everyone walks on all fours but they often lose their balance. You can see how people with Uner Tan syndrome walk in the video above.

What causes Uner Tan syndrome?

What causes Uner Tan syndrome is genetic. As you can imagine, consanguineous marriage also has a great impact on the occurrence of this disease. An autosomal recessive disorder occurs as a result of marriage and reproduction within the family. These disorders, which mean that a person receives two negatively altered (mutated) copies of the same gene from both parents, cause many diseases.

The usual basic feature of this syndrome, which is one of them, is is quadrupedal. People can stand on two legs, but when they want to move, they collapse on their hands and act as if they have the same four legs.

How was Uner Tan syndrome discovered?

First family to have quadrupedal syndrome Ulas family, Hatay’s It was found in a small village near the Iskenderun region. Later on In Adana, in Gaziantep and Canakkale Families with this syndrome also appeared in two small villages nearby.

All individuals affected by Uner Tan syndrome had a dynamic balance disorder during upright walking, and to walk on all fours It turned out that they were used to it. MRI scans showed inferior cerebellovermian hypoplasia with slightly simplified cerebral gyrus in three of the families, but appeared normal in the fourth family.

Uner Tan syndrome, ‘retrospective evolution’?

When Üner Tan discovered this situation, he said ‘retrograde evolution’ He named it, and compared the gait of people with this syndrome very much to primates. However, the term backward evolution does not apply to Üner Tan syndrome.

The reason for this is that retrospective evolution allows a lineage to ‘identify’ ancestral traits within its evolutionary process.gradual’ means to regain. So if we could evolve backwards, walking as a primate wouldn’t be in the first place.

The event that takes place in Uner Tan syndrome is evaluated as ‘atavism’ rather than evolution. ‘What about atavism?’ If you say so, let’s answer it right away. Atavism is a type of change that can reveal the characteristics of any ancestor for 1 generation as a result of mutation. If this change is permanent, backward evolution begins. Atavism and backevolution are related but not the same thing.