Developed Method That Can Change Chromosomes in Mice

an animal has chromosome It can take millions of years for the number of people to change over the course of evolution. A new study published has revealed that these changes, which take a very long time, can be made in a short time in the laboratory environment.

The scientists who carried out the research explained this long change in the course of evolution in nature. on mice managed to do. It was stated that the new technique uses stem cells and gene editing method. The study findings were shared on August 25 in the journal Science.

May reveal new information about animal evolution and help fight genetic diseases

While noting that the technique was a great success, the researchers say the findings suggest that chromosome rearrangements new insights into how it affects animal evolution He said he hopes it will come to light.

Chromosomes, which consist of DNA and proteins in the cell, are called thread-like genetic units that provide heredity in living things. Most species have a fixed number of chromosomes; however, changes may occur in these units over the course of millions of years. As a result, organisms serious physiological changes visible. If there are missing or extra chromosomes genetic diseases can cause. In addition, chromosomal fusions cancer It has also been reported to have similar results.

In the study, the researchers fused various mouse chromosomes to create different sizes. He then injected the altered genes into unfertilized eggs. Most mice with fused chromosomes exhibited abnormalities. It was stated that some mice did not develop, while others reached adulthood but remained sterile. Also, some grow much faster than normal; however, he was reported to be more anxious and physically slow. In the study, the genetic code of those who have the fusion of chromosomes 4 and 5 most successful in transferring to offspring, Thus, it was stated that new offspring could be produced.

Besides showing that the rearrangement of chromosomes is very important for reproductive isolation (preventing different species from having children by mating), the findings also show that in the evolution and survival of species proves to play an important role. More specifically, some rare changes in chromosomes helped guide the evolution of the ancestors of living things. Finally, experts believe that the information obtained is due to reasons such as chromosomal fusions. can help fight diseases also added.