CRISPR Treatment Passes Clinical Tests

A new clinical trial CRISPR gene editing technology revealed that it is possible for immune cells to recognize cancer-causing proteins. Thus, personalized and effective treatments will be realized in the fight against cancer.

In recent years, two areas of cancer research have focused on. CRISPR and immune cell regulation combined with this study. New method in cancer’s grip over 16 people tried.

Special forces from immune cells in cancer treatment

for cancer treatment a magic pill will never be found, because everyone’s cancer is treated as a separate case. Everyone’s genetic makeup is different, and genetic mutations cause cancer. As a result, a different protein must be targeted each time.

This is exactly what the new research aims at. The patient’s own T cellsIt is being redesigned to recognize and eliminate mutation-causing proteins. This army of T cells is then released into the rest of the body. To achieve this, the researchers took a blood sample from patients and a biopsy piece of tumor. Then, proteins found in tumor tissues and not found in blood were separated. Then the T cells also produce these proteins. will detect and destroy way customized. Customized T cells were transplanted into the patients.

While the disease stabilized in 5 out of 16 participants, only in 2 side effects were seen. It was noted that a limited amount of T cells was used for the experiment, although overall the effects of the treatment were limited. Specialized cells were observed to focus on cancerous structures. This confirms the researchers’ theories.

Normally customized T cells faced serious problems with solid tumors. With the new research, it has been discovered how these cells can deal with tumors and how they can be more effective. Paper describing the method developed by Joseph Fraietta and his team at the University of Pennsylvania in nature published.