Scientists have made an important discovery that will facilitate the treatment of cancerous cells. A system has been developed that will enable cancerous cells to self-destruct.
There are different types of drugs used in cancer treatment, but when it comes to affecting tumors, the drugs may not have much effect. One of the reasons for this situation is the tumors that cluster and concentrate in the inner parts of the tumors. to cancerous cells It is shown as the inaccessibility of medicines. The new method discovered by scientists opens gaps in the outer shell of tumors by triggering the “destruct buttons” of cancerous cells.
In all cells Morocco There is a receptor called Thanks to this receptor, cells destroy themselves when necessary. For this, Fas receptors need to be triggered with the right antibodies. So eliminating a cell using Fas receptors is more like putting the right key in the right keyhole and turning it than pressing the right button.
Science is at the gates of cancer’s empire of fear
from the University of California Davis and Indiana University researchers have previously “A structure whose value is not understood in cancer treatment” focused on Fas receptors, which they considered to be Although research has been conducted on Morocco so far, no study has reached the clinical testing stage.
A series of researchers recently mouse model and human cell In their studies, they revealed exactly which antibodies attach to Fas receptors and trigger the destruction of cells. Saying that previous studies were unsuccessful, researchers revealed which antibodies can bind to which parts of the receptors, called epitopes. Lead author of the study Jogender Tushir-SmithHe stated that thanks to this discovery, therapeutic treatment in tumors may be possible.
Vascular structures that keep the immune system out, or “cold tumorWhen the closed solid cells that cause the disease are destroyed, cancer treatments such as CAR-T can be performed. Under normal conditions, they are ineffective because they cannot reach the diseased cell. specially developed antibodies and the antigens will be able to fight cancer by passing through the gaps opened by antibodies targeting Morocco.
Two new antibodies against cancer cells discovered
In recent studies, researchers found that “supremely effective“. These antibodies successfully triggered the self-destruction of many cancer cells, including cancer types such as ovarian cancer. Researchers discovered two critically important parts of the Fas receptor. These parts can be used in drug development studies in the future. can play an important role. CAR-T It is stated that great progress can be made in the fight against cancer if the antibodies used for cancer can also target the cells surrounding the tumor.
Researchers say that antibodies can be developed by examining the Fas structures in patients’ cells as the treatment process begins. Cellular therapies such as CAR-T, which enable a person’s own white blood cells to specifically destroy cancerous structures much more efficient They will be able to select and eliminate tumor cells.
Research, Cell Death & DifferentiationIt was published in .