Can Older Look Young in the Future? Without Aesthetics!

In the first experiment, they gave mice some kind of chemical and whether this substance has any effect on aging observers; discovered that after administration of the aforementioned “youth medicine”, the older ones had the same effects as six-month-old mice. In another experiment, the injection of Yamanaka factor, a mixture of four molecules, into mice also showed a rejuvenation trend in animal cells.

Although these studies, which aim to reverse aging and rejuvenate, are now being tested on mice, scientists continue to work with more studies and tests. on people too predicts this effect.

Because the researchers knew that mutations were irreversible, they didn’t think it was possible in the first place to reverse this process, as mitochondrial DNA mutates with age.

prof. Dr. Sinclair and his group began by trying to remove the SIRT 1 gene from mice in their lab, with the idea that this was unlikely. Mice with the SIRT 1 gene removed, in a short time signs of aging was starting to show.

Although the professor and his team saw disruptions in the function of mouse mitochondria by gene removal, most mitochondrial proteins remain at normal levels He was very surprised to see it. Only those encoded by this organelle genome had a decreasing trend.

Stating that this situation is against the scientific world, the researchers discovered that the molecule called NAD (Nicotine Amide Dinucleotide) transfers information and coordinates between the cell nucleus and the mitochondrial genome.

in cells flow between mitochondria and genome was quite healthy, and the role of the SIRT 1 gene at this point was merely mediation.

The reason for the decrease in adequate NAD level with age has not been determined definitively yet. Without enough NAD in the body, the SIRT 1 protein cannot remove the structure called HIF-1, and in this case, the increase of HIF-1 chaos in cross gene interaction. it was causing.

In short, this interaction disorder causes the cell to lose its ability to produce energy. aging and some ailments issuing an invitation.

The deterioration experienced in this case causes the mitochondria to lose their function rapidly and to show signs of aging.

Observing these developments, scientists discovered that by increasing the amount of NAD produced in cells, they could rapidly increase mitochondria function. If enough of this substance is taken daily, some of the problems that come with aging could be shelved.

In addition, the HIF-1 protein has a significant association with cancer detected. Under normal conditions, HIF-1 activates when the body is deprived of oxygen and remains silent until old age. In this direction, it was stated that the increase in the risk of cancer as aging occurs depends on the HIF-1 protein.

However, scientists underline that DNA damage or shortening of telomeres will never change over time, and that this drug is not a “treatment for aging” alone.

Another researcher who continues to work on the subject, Dr. Gomes, “There are many factors of aging. There is no single element to treat. Therefore, it is very difficult to treat all aging factors.” he stated.

Conducting this research from the very beginning, Prof. Dr. Although Sinclair and his team want to start experiments in a few years; Dr. Gomes, in order for this treatment to be tested in humans More research and studies need to be done emphasizes.

prof. Dr. Tim Spector shares the same view and says the following on the subject:The finding that some parts of the aging process are reversible is pretty exciting. But with experiments on mice aging without side effects in humans There’s a big difference between proving that it can indeed be undone.”

The researchers are now also looking at the long-term consequences of the NAD-producing compound in mice and how it affects the mouse as a whole.

In addition, the rare mitochondrial diseases and Type 1-Type 2 diabetes Studies are ongoing to see if it can be used to safely treat more common diseases, such as

prof. Dr. Sinclair, the compound was given to mice. a healthier and longer life He also plans to influence his work.

In another experiment on mice to reverse aging, researchers in the US created a type of gene therapy that regenerates aged cells and makes them younger than the biological markers used to measure the effects of aging.

Expressing that many age-related diseases can benefit from this approach, scientists say that if they can be 100% sure that this gene therapy can combat health problems, this finding will be supported. Contribution to the medical world He said it could be.

The adult cells of these experimental mice were produced by a mixture of four molecules known as Yamanaka factors, which can form nearly any tissue in the body. return to young stem cells was aiming.

The researchers discovered that mice that received Yamanaka factors for several months resembled younger animals in many ways, particularly their skin and kidneys.

Experiments performed when animals were 12 to 15 months old failed to apply for 1 month. Rejuvenation is more effective when performed for a long time in the range of 7-10 months. confirmed that.

However, scientists who continue their research and studies on the experiment have determined the Yamanaka factors. about testing on humans not quite sure yet. This is because reprogrammed cells are likely to cause the formation of cancerous tissue clumps called teratomas.

Although the final stage of studies has largely shown that tissues can be rejuvenated without such risks, experts aim to partially reprogram cells effectively and safely, rather than using Yamanaka factors to rejuvenate older people. new drugs may be needed. is thinking.

Research groups aim to reverse aging and minimize the risks in these applications and Timing, combination and dose of Yamanaka factors continues to work on it.