A team of researchers from the University of California announced that their discovery of a protein found in tumor cells could lead to highly effective treatments for some of the deadliest cancer diseases.
CancerIt is known as one of the biggest threats of our time. Studies on this disease, which has not yet found a definitive treatment, are continuing. As a result of a study conducted by researchers at the University of California Irvine one of the deadliest types of cancer even in some effective treatment methods discovery was made.
GLI1 proteinsare effectors of the Hedhehog (Hh) signaling pathway, a signaling pathway that transmits information necessary for proper cell differentiation to embryonic cells. This protein embryo development in many cell types and most organs during of cell fate determinationplays a role in reproduction and modelling. The research team has made a new discovery regarding the GLI1 protein, which is important in cell development but is also known to cause various cancers.
Cancer can be cured without the side effects of chemotherapy
The scientists who conducted the research stated that in some cases, proteins in one pathway can work proteins in the other pathway. The scientists explained the aim of the study as discovering how the molecular mechanism works that causes the GLI1 protein to be activated by other proteins in this very complex system.
GLI1, SUFU a called to protein tightly connected. The SUFU protein suppresses GLI1, preventing it from penetrating the cell nucleus and spreading its genes. Scientists have identified a protein that can be phosphorylated on or onto the GLI1 protein. phosphate group examined seven regions that can be transferred. Of these seven regions, three that weakened the bond were identified. As a result, the activation of GL1, that is, the entry of this protein into the cell nucleus, causes cancer or uncontrolled cancer way to grow They discovered why.
However, if scientists can understand exactly what happens in a particular type of cancer or tumor as a result of this situation, they will be able to treat the disease or the patient. a special drug they think it might be possible to find out. With this discovery, patients treatment without the side effects of chemotherapy can.
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Source :
https://scitechdaily.com/how-a-certain-protein-can-cause-deadly-cancers/