A personalized mRNA vaccine that triggers the immune system against brain tumor has been developed. The vaccine, which was tested on four people, gave successful results.
Studies continue unabated to prevent brain tumor, one of the most deadly diseases. A new study published is a research developed by scientists at the University of Florida in the USA. mRNA vaccine reveals that he has the potential to do so.
The vaccine, which is still in its early stages, is described as “personalized” because it is developed specifically for each patient. Its purpose is to protect the body’s immune system against the most lethal and aggressive form of the disease. Can trigger it to counterattack.
Tests performed on four patients gave successful results.
Researchers say first human trials of vaccine over 4 people announced that it happened. In the results, they observed that the vaccine was able to trigger the immune response to fight malignant brain tumor, also known as “Glioblastoma”. The findings were published on Cell. It should be noted that the disease normally requires surgery, radiation and sometimes chemotherapy to treat it, and the mortality rate is seriously high.
The vaccine reprogrammed the immune system to attack the cancer. After applied After just two days, the immune response observed. It was also reported that the results were similar to experiments that researchers previously conducted on dogs and mice with brain tumors. Now, the Phase 1 pediatric clinical trial phase will begin. Experts say they plan to try the vaccine on more cancer patients. For the next tests 24 people will be selected Among the information received.
The vaccine uses regeneration of lipid nanoparticles and mRNA technology, just like the COVID vaccines, and uses the immune system to fight cancer. For its use, patients samples of tumor cells being taken. In this way, vaccines are developed differently for each patient. This is why it is called “personalized vaccine”.
Another difference is that it has a newly designed complex distribution mechanism. Instead of injecting as single particles, they inject as clusters of particles that surround each other like onions. In this way, co-author Elias Sasyour explains, the immune system can interact with single particles. that you can be stimulated much better and says it can trigger its response against the tumor.
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Of course, it is too early to talk about the new vaccine right now. However, if it is successful, we can say that it could save the lives of many people. We will wait and see what the results of clinical tests will be. We should also note that this is not the first personalized mRNA vaccine to come out recently. In recent weeks, we have seen that an mRNA vaccine developed against skin cancer was successful in human trials.