Many Men Lose Y Chromosomes As They Age

Errors in the human gene are considered a part of life. As we age and the number of DNA increases, minor problems begin to appear in our genes, such as a misplaced letter or repeating some mistakes. These errors accumulate over time and can form a mosaic of cells with unique codes in our body. Some cells may even lose all their chromosomes.

Scientists many men loses Y chromosomes as you get older He knew and was looking for reasons. The extent of the loss of the Y chromosome was unknown, and it was even considered a sign of aging, such as graying of hair with age, which had no clinical significance. However, the latest research study revealed that the loss of the Y chromosome is extremely important.

Y chromosome loss causes serious heart disease

Chromosomes, a set of DNA found in pairs in every cell, XX in women, in men if XY It has an X and a Y chromosome. As a result of the research, the loss of Y chromosome in the cell is called mLOY, age 70 and above in 40% of men turned out to occur. Even if the Y chromosome has long been considered a shrinking genetic space filled with junk DNA fragments, loss of the Y chromosome can cause serious health problems.

A research team announced that they discovered that men over 60 die faster than women and age faster biologically. With this new research why men die earlier than women Certain clues have emerged. In experiments on mice, a special gene editing tool was used to better understand the effects of loss of the Y chromosome in the blood. CRISPRwas used. Loss of Y chromosome hardens heart tissues in mice injected with specific genes and heart failure associated with heart fibrosis It was found to cause a condition known as As a result of this situation, it was shared by the research team that early deaths were seen in mice with Y chromosome loss.

Why Y chromosome loss is so deadly may have been found

The researchers also analyzed data compiled from the UK Biobank study, which was nearly 10 years of research, to compare the findings with human data. As a result of investigations and experiments, the effects of Y chromosome loss in men were thoroughly investigated. As a result, Y chromosome loss is more die young and Alzheimer’s as well as being more likely to suffer from age-related ailments such as heart diseases and found that it had a direct effect on heart failure.

The research team also discovered that men with mLOY in their blood at the start of the study had an increased risk of dying from heart failure and other cardiovascular diseases during the mean 11-year follow-up period. In other words, as a result of this research, it is considered as concrete evidence that the loss of the Y chromosome directly causes harmful effects on male health.

There’s no cure for the condition yet, but researchers say quitting smoking may be a smart move. Because research also shows that men who smoke are three times more likely to show a loss of Y chromosomes in their blood cells than non-smokers.