Gene Found to Shape Immunity Against COVID-19

Since the pandemic began last year, millions of people have to COVID-19 As a result of his capture, he either died or was taken to the hospital or survived the disease without any accident by staying at home for 1 to 2 weeks. Scientists have investigated why people are so susceptible to the virus in their latest study. give different responses They think they’ve found it.

In the aforementioned study, scientists identified the causes of COVID-19. SARS COV-2 individuals infected with the virus, OAS1 He thinks it responds differently to the virus at an early stage, thanks to a gene called his name—which codes for a certain protein.

Some people have a more protective variant of the OAS1 gene:

Under normal conditions, when the cell is infected, the OAS1 protein triggers events that lead to detecting the virus and activating the RNA-killing enzyme. But MRC-University of Glasgow Virus Research Center Scientists have suggested that some people carry a more protective form of OAS1.

What is meant by this protection is the protein encoded by the OAS1 gene. adding a lipid molecule. Viruses in the COVID-19 family hide inside cells and transmit their genomes. from lipids OAS1, which has become more protective because they multiply in the vesicles formed, detects the virus more easily. Therefore, it also directs cellular weapons better.

This is not just a theory. Looking at hospitalized patients, the more protective version of the gene can be found in severe disease. better results appeared to show. Those who carried the gene that had not yet become protective had worse outcomes, as you can imagine.

By comparison, the probability of these people being admitted to intensive care and dying 1.6 times more was stated.

If the virus exceeds the OAS1 gene, unvaccinated populations will face worst-case scenarios:

One of the predicted sources of Sars-CoV-2 virus horseshoe bats is presumed to be. In these animals, the protective gene in question is approximately 55 million years ago is thought to have disappeared. In other words, Sars-CoV-2 virus has not been exposed to this gene in history. didn’t have to adapt. That’s why it’s still effective.

But researchers have found that the corona virus that caused the SARS epidemic in 2003 was derived from the OAS1 protein, which had become more protective. learned to run told. If the same happens for Sars-CoV-2, the virus can be found in unvaccinated populations. stronger and more contagious The researchers said that the variants on the agenda should be followed closely.