Scientists, COVID-19 risk of death identified a gene that they thought increased the Researchers have found that the gene in question can cause a person’s severe infection He thinks he’s causing it. Also, because of problems in this gene, the risk of death is doubled for people under the age of 60.
LZTFL1 geneagainst infections lung regulates cells. But this is not the case in a risky variant of the gene. Because a new study shows that the lungs of this gene are the coronavirus factor. SARS COV-2It shows you didn’t fight hard enough to protect it from.
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Does not adequately protect the lungs against COVID-19 infection!
The type of gene that increases the risk of serious illness and death of COVID-19 has been the subject of discussion. The gene in question south asia In 60 percent of people of origin, Europe In 15% of people of origin, Africa 2.4 percent of people of origin and East Asia present in 1.8 percent of people of ancestry.
Leader of the COVID-19 study from Oxford University professor of genomics James Daviesspoke about this study. Live ScienceSpeaking to Dr. “It’s one of the slightly more common genetic signals,” Davies said. That’s why it’s the most important genetic target in COVID-19.” said.
In addition, the research team emphasized that no gene can fully explain this situation. In this regard, Dr. Davies said many factors play a role. For example, a person how long you have been exposed to the virus and when he was sick of health care We can include quality. With this, age, other health conditions and socio-economic The situation also affects the severity of the disease. To give an example in this regard, India is quite ideal. because delta variant During the wave, there was no room in the hospitals and serious problems were experienced in the country.
With this, LZTFL1 They suggest that the risky type of the gene has a significant effect. Researchers found that this gene 20 to 60 years stated that it increases the risk of COVID-19 in people among Moreover, the risk doubles for every ten years in this age range.
Scientists meticulously studied the gene
The researchers first genome-wide conducted a study. They compared the genomes of a group of patients with severe COVID-19 with respiratory failure to the genomes of a control group with no evidence of infection or a history of infection with mild symptoms. The team found that there was a set of genes that were more common in patients with severe infections than in the control group.
With all these findings, at Oxford University co-leader, professor of gene editing Jim HughesIt’s not easy to figure out which of these genes increases risk, he said. Hughes noted that variations in genes are often inherited as a block. So it makes it difficult to figure out which variation is responsible.
While genetic sequences are found in every cell in the body, they only affect a few cell types. Researchers tried to detect the gene type in question with a different method. team, a function of accelerator and to the DNA sequence based on cell type used machine learning to predict about
In the study, the researchers found that the gene in question was in lung cells. Finally, the team stressed that more research is needed for proof. In addition, the team recently Nature GeneticsHe published this work in