Crown-Like Structures Surrounding Breast Tumors Discovered

Cancer is also a bigger problem than COVID-19. Scientists continue to make important strides in the diagnosis and treatment of cancer. In recent years, there has been a great improvement in the early diagnosis of breast cancer with blood tests. Today, however, a sad development has emerged in the field of cancer treatment.

University of SouthamptonA new research study performed in . “crown-like structures” discovered that it could hinder breast cancer treatment. According to the researchers, the new findings emerging as a result of this study, HER2 positive that is, it could potentially be used to develop a personalized treatment for patients with excess cancer-producing cells.

Overweight breast cancer patients have a higher mortality rate

Adipose tissue in the healthy human breast and body fat is an important component. The most important reason for the increased risk of developing breast cancer is is a high body mass index. According to studies, mortality rates in breast cancer are higher in patients with cancer who are overweight than in patients with a healthy body mass index.

In patients with high body mass index, increased body fat surrounding the breast, macrophage called inflammatory immune cells may cause the breast to collect in the adipose tissue. These macrophages can then surround these fat cells to form crown-like structures. This is the breast of tumors to start and to grow It causes an inflammatory environment that can lead to breast cancer. How these crown-like structures affect breast cancer progression and how they respond to treatment is still unknown.

Professors Stephen Beers, Ramsey Cutress and Dr. A research team led by Charles Birts examined samples from a group of HER2+ breast cancer patients to investigate the link and influence between a high body mass index and the formation of crown-like structures.

Cancer spreads faster in obese people

According to the results published in a scientific research journal, over-weight or obesity Significantly more crown-like structures were seen in the adipose tissue surrounding the tumor in cancer patients with cancer. It turned out that this caused the disease to spread more quickly.

Researchers further study the surface of macrophages in these crown-like structures. CD32B potential molecular biomarker they determined. Obesity and overweight patients with subsequent biomarkers, to trastuzumab treatmenti.e. humanized intravenously given to treat certain types of breast cancer and stomach cancer monoclonal antibody therapy their response was considerably lower than for people of more normal weight.

According to Stephen Beers, Professor of Immunology and Immunotherapy at the University of Southampton, this study highlighted how effective trastuzumab therapy is in patients with no biomarkers. Beers, “These patients may benefit from lower doses of anti-HER2 therapy that can minimize the side effects they experience. We need further studies with more patients to help confirm these initial findings.‘ he concluded.

Beers and his research team are now looking for ways to alter the behavior of these crown-like structures to improve responses to breast cancer treatment and for treatment outcomes.