By trying a treatment by combining two different drugs, scientists managed to stop a deadly type of cancer, small cell lung cancer, in a mouse. Now researchers are preparing to experiment on humans.
one of humanity’s greatest enemies cancer While the fight against the disease continues, scientists continue to work to find new treatments for this disease. A new drug tested on mice has the potential to offer new hope against this relentless disease.
Scientists who went to combine the two drugs, in this way, that both drugs failed to reach achieved a success. The new drug mixture stopped the deadly small cell lung cancer in the mouse used for the experiment.
Cancer cells are prevented from forming resistance
The first of the drugs used by scientists, cyclophosphamide It has been a drug known as a drug called immunosuppressant used in cancer treatment since the 1980s. In the past, this substance has been replaced by alternatives that are known to have fewer side effects. Cancer cells respond quickly to this drug, whether cyclophosphamide or its alternatives are used. immunity was developing.
The team performing the experiment small cell lung cancer He also revealed how he was able to develop immunity to this drug. Afterwards, they carried out various studies to eliminate this problem.
The method developed by the researchers is essentially used by cancer cells to create cyclophosphamide resistance. realization of repair processes is stopping. The research team had previously RNF113A The team that identified the gene that plays a role in the repair mechanism of cancer cells, also stands out as one of the factors facilitating this study.
In more extensive studies, RNF113A SMYD3 The researchers, who revealed that it is regulated by a protein called the SMYD3 protein, and that it is much more dense in cancerous structures, conducted studies targeting the SMYD3 protein. Thus, the cancer tissue, which was suppressed by cyclophosphamide, was prevented from repairing itself and growing again.
Researchers now for human studies Phase 1 clinical trials intends to start. It is predicted that this treatment method may also work in some types of cancer that have gained resistance to other treatments. Research, Cancer Discovery was published in the journal.
Source :
https://www.sciencealert.com/experimental-drug-treatment-stops-a-deadly-form-of-lung-cancer-in-mice