Although bones can repair themselves when damaged, teeth cannot do the same. The fact that teeth do not have the ability to heal and regrow on their own causes thousands of people around the world to face the problem of toothlessness. Japanese researchers have rolled up their sleeves for a drug that will grow new teeth. Here are the details…
Are you ready to grow new teeth with a medicine?
Although teeth, like bones, are the hardest material in our body, they do not have the important properties that humans need, such as self-repair or regrowth. However, new developments in the scientific world have revealed that we can leave the problem of toothlessness behind.
Japanese researchers announced that they are continuing their work on a new drug that will allow human teeth to regrow. It was announced that the first trials on humans will begin in September. The first patients will receive the drug intravenously and the process will be monitored.
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Katsu Takahashi, head of dentistry at the medical research institute at Kitano Hospital, made a statement about the drug:
“We want to do something to help patients suffering from tooth loss or missing teeth. “Although no treatment has yet been found that offers a permanent solution, we think people have high expectations for tooth growth.”
The drug will be the culmination of years of work around Uterine sensitization-associated Gene-1 (USAG-1), an antibody that inhibits tooth growth in mice and ferrets.
In 2021, scientists from Kyoto University discovered an antibody that disrupts the interaction between molecules known as USAG-1 and bone morphogenetic protein (BMP) using monoclonal antibodies, a technique often used in the fight against cancer.
Katsu Takahashi from Kyoto University, one of the co-authors of the study, also spoke on this subject:
“We knew that suppressing USAG-1 benefits tooth growth. But we didn’t know if it would be enough. “Weasels are diphyodont animals with dental structures similar to humans.”
Now, with new experiments to be carried out, we will see what results these drugs will give to people. Human trials, which will begin in September, will last for 11 months on 30 men between the ages of 30 and 64 who are missing at least one tooth.
To prove the effectiveness and safety of the drug, the drug will be administered by injecting it directly into the vein. In addition, no side effects have been observed in studies conducted on animals so far.
If the studies in September yield the desired results, Kitano Hospital will administer the drug to children between the ages of 2 and 7 who are missing at least four teeth. Japanese researchers are preparing to launch a drug that will regrow teeth by 2030.
What do you think about this development?