Discovery From Aziz Sancar That Could Cure Brain Cancer

Academician, molecular biologist and biochemist, one of Turkey’s leading scientists Aziz Sancarfor his work in 2015 mapping how cells repair damaged DNA and preserve genetic information at the molecular level. Nobel Prize in Chemistry He was awarded the Nobel Prize and became the second Turk to receive the Nobel Prize.

Now it turns out that the 75-year-old scientist has made another discovery. According to an article written by Orhan Bursalı from Cumhuriyet, Sancar and his team made an important breakthrough in the treatment of brain cancer.

The discovery was made by chance

According to the news, Sancar and his team found that the materials used in the experiments carried out in the laboratories EdU molecule discovered that it can be used in brain cancer. While it was stated that the findings of the study were published in the journal PNAS, it was also stated that Sancar spoke about the subject in the early stages. The famous scientist stated that they made their discovery by chance and this would make many people happy: “This is a very surprising discovery, a great coincidence. While doing another experiment, something very different happened that shocked us all of a sudden.”

It was also stated in Bursalı’s news that Sancar briefly explained his invention. The famous scientist stated that they were investigating a subject they were curious about on DNA repair. Sancar won the Nobel Prize Human Nucleotide Excision Repair SystemIt cuts out and repairs damaged 26 nucleotide sections of DNA. Sancar also proved this in the test tube; but they wondered if this is the case inside the human cell, he said.

Cells almost entered the repair cycle

Stating that they were investigating whether more than 26 nucleotides were removed or more nucleotides were added, the scientist stated that they used a molecule called EdU for this. Stating that the results that emerged at this time shocked them, Sancar said it was as if the molecule was found in intact DNA. pretending to be damaged and activates the repair mechanism.

To expand a little more, the molecule was placed in the environment of intact cells. Afterwards, it was seen that the cell activates the repair mechanism and cuts out the molecule. When the extracted molecule was released, it re-entered the genome and the same thing happened again. Stating that this cycle continues like this, Sancar finally Cell that cannot cope with EdU stated that he was dead. The scientist emphasizes that in this way, it is understood exactly how the molecule kills the cell, and that it can be used for cancer cells.

“EdU molecule can kill tumor without damaging neurons”

Let’s talk about brain cancer. According to the statements, the EdU molecule can easily pass into the brain by crossing barriers, unlike chemotherapy drugs. Sancar also states that EdU can be used against cancer due to its cell-killing properties:EdU If given to a patient with brain cancer, it goes to the brain, It enters the DNA of cancerous cells and kills the tumor without damaging the neurons. We have reached the conclusion.”

The Nobel Prize-winning scientist now states that they will start working with a leading expert on brain tumors and carry out experiments. We will see later whether the exciting discovery will be a solution to the brain cancer that affects millions of people.