A Promising Advance in Cancer Treatment

Cancer is one of the diseases for which technology, which is developing more and more every year, cannot find a cure. No cure has yet been found that can completely eradicate this disease, but researchers at the University of Washington discovered that a booster protein produces exactly 10,000 times more immune cells against cancer.

Our immune system is the strongest line of defense against many diseases, including cancer. Cancer has some cunning methods to evade detection and weaken immune cells. In recent months, Japanese researchers have discovered that a cancer patient T cells extracts, genetically engineered it to target specific cancer cells, and puts it back in the body to hunt the cancer. CAR T cell immunotherapy had done the experiment. This time, a different team has used similar treatment, adding a new dimension to the battle against cancer with CAR T cell immunotherapy.

A group of researchers from the University of Washington booster protein discovered that supplementation could significantly improve the outcome of cancer immunotherapy. Experiments in mice showed that the protein 10,000 times more immune cell revealed that all mice survived throughout the experiment.

The treatment method was developed by changing the structure of the protein.

In the new study, scientists investigated ways to fight cancer by increasing the number of T cells. Said to be all-natural to boost T cell production in the body’s disease state interleukin-7 Using a protein called (IL-7), the researchers changed the structure of the natural protein, which does not normally live in the body for a very long time, allowing it to stay in the body for weeks.

The team injected this long-lived IL-7 into mice on different days. In the test, some mice received no immunotherapy, while others received CAR T cell therapy without the IL-7 protein. When tumor-bearing and immunodeficient mice were injected with a long-acting IL-7 protein following CAR T cell therapy, it was observed that CAR T cells in these mice increased more than ten thousandfold compared to mice that did not receive IL-7. It was also observed that these CAR T cells fought against the harmful tumor for a longer period of time.

Human trials could begin soon

immunotherapy

Thanks to this enhanced treatment, the survival times of the test mice were even longer. Tumors in the body of each mouse that received IL-7 protein with CAR T cell therapy on the 35th day undetectable shrunk. In addition, each of the mice lasted 175 days. throughout the experiment was able to survive. In contrast, mice with only immunotherapy treatment an average of 30 days He was found to have survived.

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There may be cases where experiments in mice do not show the same effect in humans, but according to the statements made by experts, clinical trials of CAR T cell therapy enhanced with IL-7 protein are expected to begin soon in patients with a type of lymphoma.

Source :
https://newatlas.com/medical/cancer-immunotherapy-booster-10-000-times-more-cells/


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